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Cat. No. Product Name Information
PC-42865

CP-673451

PDGFR inhibitor

CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively.
PC-42630

TSU-68

TSU-68 (Orantinib, SU6668) is a small-molecule, ATP-competitive inhibitor of angiogenic related RTKs KDR, PDGFRβ, FGFR1.
PC-42555

PP121

PDGFR inhibitor

A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM.
PC-47008

Seralutinib

PDGFR inhibitor

Seralutinib (GB002) is a potent, selective kinase inhibitor that targets PDGFRα/β, CSF1R, and c-KIT, and increases BMPR2, shows potential for treatment of pulmonary arterial hypertension.
PC-62329

SU 16f

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively.
PC-62328

JNJ-10198409

JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM.
PC-62019

MK-1

MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation.
PC-61281

AG-1296

A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells.
PC-61280

AG-1295

A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
PC-70043

CGP-53716

A potent protein tyrosine kinase inhibitor that shows selectivity for PDGFR in vitro and in cells.
PC-42725

N-Desethyl Sunitinib

The active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor for the treatment of RCC and imatinib-resistant GIST..
PC-42529

Toceranib phosphate

An ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit.

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