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Cat. No. Product Name Information
PC-49287

AMG PERK 44

PERK inhibitor

AMG PERK 44 (AMG44) is a potent, highly selective, and orally active protein kinase RNA-like ER kinase (PERK) inhibitor with IC50 of 6 nM, inhibits cellular PERK autophosphorylation (pPERK) with IC50 of 84 nM.
PC-38450

cis-ISRIB

PERK inhibitor, eIF2α inhibitor

cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.
PC-72030

PERK activator MK-28

PERK activator

PERK activator MK-28 is a potent, selective small molecule PERK activator with EC50 of 490 nM.
PC-35976

CCT020312

PERK activator

CCT020312 (CCT-020312) is a small molecule PERK activator, inhibits pRB phosphorylation in HT29 colon carcinoma cells with EC50 of 5.1 uM.
PC-43062

ISRIB

PERK inhibitor

ISRIB trans-isomer is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.
PC-45410

GSK-2606414

PERK inhibitor

GSK-2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
PC-21218

HC-5404

PERK inhibitor

HC-5404 (LY-4) is a potent, selective and orally active inhibitor of PKR-like endoplasmic reticulum kinase (PERK, EIF2AK3) with IC50 of 1 nM.
PC-20455

LDN‑87357

PERK inhibitor

LDN‑87357 is a novel small‑molecule PERK inhibitor.
PC-49644

PERK inhibitor 28

PERK inhibitor

PERK inhibitor 28 is a potent, selective, and orally bioavailable PERK inhibitor with biochemical IC50 of 2 nM, and cellular IC50 of 9 nM in p-eIF2α cellular TR-FRET assays.
PC-49643

GSK-2656157

PERK inhibitor

GSK2656157 (GSK 2656157) is a potent, selective and ATP-competitive inhibitor of PERK with biochemical IC50 of 0.9 nM and cellular p-PERK IC50 of 30 nM.

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