| Cat. No. |
Product Name |
Information |
| PC-60898 |
Capzimin
Rpn11 inhibitor
|
Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 (PSMD14) with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol). |
| PC-42595 |
MLN9708
Proteasome inhibitor
|
Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42470 |
Bortezomib
|
Bortezomib (PS-341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome. |
| PC-42598 |
Carfilzomib
|
Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM. |
| PC-42242 |
RA190
Rpn-13 inhibitor
|
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM). |
| PC-22061 |
hRpn13 inhibitor XL44
hRpn13 inhibitor
|
XL44 is a potent, specific hRpn13 (proteasome subunit hRpn13)-binding compound, binds to hRpn13 Pru domain, induces loss of hRpn13 Pru and hRpn13-dependent apoptosis. |
| PC-22005 |
Davelizomib
|
Davelizomib is proteasome inhibitor with antineoplastic effect. |
| PC-21916 |
Epoxomicin
Proteasome inhibitor
|
Epoxomicin (BU-4061T) is a potent, selective and irreversible proteasome inhibitor, covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. |
| PC-21189 |
TCL-Ester
Rpn-13 inhibitor
|
TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13. |
| PC-21188 |
TCL-1
Rpn-13 inhibitor
|
TCL-1 is a non-covalent ligand targeting the Pru domain of Rpn-13, TCL-1 binds to the Pru domain at the Rpn-2 docking site, affects proteasome-mediated proteolysis. |
| PC-21187 |
KDT-11
Rpn-13 inhibitor
|
KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells. |
| PC-20757 |
BT317
LonP1 inhibitor
|
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines. |
