| Cat. No. |
Product Name |
Information |
| PC-42439 |
YM-155
Survivin inhibitor, RIPK2 inhibitor
|
Sepantronium bromide (YM-155) is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM, targets RIPK2 kinase activity. |
| PC-45707 |
RIPK2 inhibitor 2
RIPK2 inhibitor
|
RIPK2 inhibitor 2 (RIPK2-IN-2) is a potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor. |
| PC-42102 |
GSK-583
RIPK2 inhibitor
|
GSK-583 is a potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively. |
| PC-45564 |
WEHI-345
RIPK2 inhibitor
|
WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM. |
| PC-42301 |
RIPA-56
RIPK1 inhibitor
|
RIPA-56 is a highly potent, selective, stable Receptor-interacting protein kinase 1 (RIPK1, RIP1) inhibitor with IC50 of 13 nM. |
| PC-42065 |
GSK-481
RIPK1 inhibitor
|
GSK-481 (GSK481) is a highly potent, monokinase selective and ATP-competitive inhibitor of RIP1 kinase (RIPK1) with biochemical IC50 of 10 nM. |
| PC-24512 |
SZM-1209
RIPK1 inhibitor
|
SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM. |
| PC-24511 |
SIR1-365
RIPK1 inhibitor
|
SIR1-365 is a highly potent, selective, and metabolically stable allosteric kinase inhibitor of RIPK1. |
| PC-24510 |
RIPK1 inhibitor 13c
RIPK1 inhibitor
|
RIPK1 inhibitor 13c is a potent, selective RIPK1 inhibitor with IC50 of 59.8 nM and Kd of 3.5 nM, effectively prevented the necroptosis (HT-29, EC50=4.58 nM) by inhibiting phosphorylation of RIPK1/RIPK3/MLKL single pathway. |
| PC-24135 |
Fosizensertib
RIPK1 inhibitor
|
Fosizensertib is a potent, selective RIPK1 inhibitor. |
| PC-23024 |
Citronellol
RIPK1 agonist
|
Citronellol is an orally active inducer of apoptosis and RIPK1 agonist. |
| PC-22669 |
Nec-1s
Necroptosis inhibitor, RIPK1 inhibitor
|
Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO. |
