| Cat. No. |
Product Name |
Information |
| PC-24135 |
Fosizensertib
RIPK1 inhibitor
|
Fosizensertib is a potent, selective RIPK1 inhibitor. |
| PC-23024 |
Citronellol
RIPK1 agonist
|
Citronellol is an orally active inducer of apoptosis and RIPK1 agonist. |
| PC-22669 |
Nec-1s
Necroptosis inhibitor, RIPK1 inhibitor
|
Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO. |
| PC-22668 |
Necrostatin-5
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1). |
| PC-22667 |
Necrostatin-1
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-1 (Nec-1) is a potent, specific and BBB-permeable necroptosis inhibitor with EC50 of 490 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1) with EC50 of 182 nM. |
| PC-21707 |
RIPK1 inhibitor 62
RIPK1 inhibitor
|
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3. |
| PC-21572 |
AC-003
RIPK1 inhibitor
|
AC-003 is a novel oral small-molecule inhibitor of receptor interacting protein kinase 1(RIPK1) and has the potential for treating idiopathic pulmonary fibrosis. |
| PC-20562 |
aYM155
YM155 prodrug
|
aYM155 is a brain-penetrating prodrug form of YM155 (Cat. PC-42439, potent survivin inhibitor), displays potent cell killing activity against a broad panel of patient-derived GBM cancer stem-like cells (IC50=0.7-10 nM). |
| PC-73178 |
GSK2983559
RIPK2 inhibitor
|
GSK2983559 is a potent, selective and oral active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 5-10 nM. |
