| Cat. No. |
Product Name |
Information |
| PC-49781 |
MC0704
STAT3 inhibitor
|
MC0704 (MC-0704) is a novel synthetic STAT3 pathway inhibitor with IC50 of 2.13 uM. |
| PC-49596 |
SOST inhibitor S6
Sclerostin inhibitor
|
SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis. |
| PC-49462 |
WB436B
STAT3 inhibitor
|
WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM. |
| PC-49434 |
DR-1-55
STAT3 inhibitor
|
DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3. |
| PC-49156 |
KS10076
STAT3 inhibitor, Metal chelator
|
KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM. |
| PC-49088 |
STX-0119
STAT3 inhibitor
|
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM. |
| PC-47064 |
ODZ10117
STAT3 inhibitor
|
ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines. |
| PC-47050 |
LLL12B
STAT3 inhibitor
|
LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion. |
| PC-38849 |
W1131
STAT3 inhibitor
|
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo. |
| PC-38756 |
pan-IFN inhibitor 5k
JAK-STAT inhibitor
|
pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro. |
| PC-73189 |
WP1066
STAT3 inhibitor
|
WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM. |
| PC-73110 |
SI-109
STAT3 inhibitor
|
SI-109 (SI 109) is a selective, high-affinity and cell-permeable STAT3 SH2 domain inhibitor with Ki of 9 nM, component of STAT3 degrader SD-36 (PROTAC). |
