| Cat. No. |
Product Name |
Information |
| PC-35089 |
PM-43I
STAT5/6 inhibitor
|
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM). |
| PC-63206 |
KI16
STAT3 inhibitor
|
KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain. |
| PC-63164 |
TRi-1
TXNRD1 inhibitor
|
TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2. |
| PC-63081 |
PG-S3-001
STAT3 inhibitor
|
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance. |
| PC-62863 |
NSC 368262
STAT3 inhibitor
|
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers. |
| PC-62732 |
ML115
STAT3 agonist
|
ML115 is a potent, selective STAT3 agonist with EC50 of 2.0 nM, inactive against the related STAT1, STAT5 and NF-κB anti-targets. |
| PC-62576 |
QD 232
STAT3 inhibitor
|
QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration. |
| PC-62556 |
AC-4-130
STAT5 inhibitor
|
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
| PC-62521 |
NSC 311068
STAT3/5 inhibitor
|
NSC 311068 is a small molecule that directly tragets and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62520 |
NSC 370284
STAT3/5 inhibitor
|
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62519 |
UC-514321
STAT3/5 inhibitor, TET1 inhibitor
|
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62444 |
Pimozide
STAT5 inhibitor, USP1 inhibitor
|
Pimozide (R6238) is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5. |
