| Cat. No. |
Product Name |
Information |
| PC-62432 |
Hydrazinocurcumin
STAT3 inhibitor
|
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets. |
| PC-62378 |
InS3-54
STAT3 inhibitor
|
InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
| PC-62377 |
InS3-54A18
STAT3 inhibitor
|
InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties. |
| PC-62347 |
S3I-M2001
STAT3 inhibitor
|
S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers. |
| PC-61683 |
Juglone
STAT3 inhibitor, Pin1 inhibitor
|
Juglone (5-HN) is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities, inhibits STAT3 with Ki of 13.36 uM in FP assays. |
| PC-61669 |
FLLL31
STAT3 inhibitor
|
FLLL31 (Tetramethylcurcumin) is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells. |
| PC-61668 |
FLLL32
STAT3 inhibitor
|
FLLL32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM). |
| PC-61667 |
XZH-5
STAT3 inhibitor
|
XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes. |
| PC-61666 |
SD-1029
STAT3 inhibitor
|
SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells. |
| PC-61660 |
LLL3
STAT3 inhibitor
|
LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities. |
| PC-61629 |
Capstafin
STAT5b inhibitor
|
Capstafin is a phosphorylation of capsaicinoid derivative that acts as a highly potent, selective inhibitor of STAT5b with Ki of 0.34 uM. |
| PC-61628 |
STAT5b inhibitor 7
STAT5b inhibitor
|
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM. |
