| Cat. No. |
Product Name |
Information |
| PC-60456 |
Cucurbitacin I
JAK/STAT3 inhibitor
|
Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM. |
| PC-60417 |
Debio 0617B
Multi-kinases inhibitor
|
Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM). |
| PC-42174 |
BP-1-102
STAT3 inhibitor
|
BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM. |
| PC-42160 |
HO-3867
STAT3 inhibitor
|
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
| PC-42175 |
SH5-07
STAT3 inhibitor
|
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM. |
| PC-45109 |
SH-4-54
STAT3 inhibitor
|
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM. |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-26626 |
WB518
STAT3 inhibitor
|
WB518 is a specific small molecule STAT3 inhibitor, inhibits the phosphorylation of STAT3 Tyr705 (Y705). |
| PC-26586 |
STAT3-IN-12
STAT3 inhibitor
|
STAT3-IN-12 is a potent. selective STAT3 inhibitor, inhibits IL-6 induced JAK/STAT3 signalling pathway activation, inhibits cancer cell growth, migration, and induces cell apoptosis as well as cycle arrest. |
| PC-26446 |
ISS610
STAT3 inhibitor
|
ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1. |
| PC-26387 |
Magnesium isoglycyrrhizinate hydrate
STAT3 inhibitor
|
Magnesium isoglycyrrhizinate (MgIG) is a stereoisomer of glycyrrhizic acid with more potent hepatoprotective activity and less side effects than glycyrrhizic acid, inhibits inflammatory response through STAT3 pathway, also inhibits the activation of the LPS/TLRs/NF-κB signaling pathway in liver injury caused by anti-tuberculosis (anti-TB) drugs. |
