| Cat. No. |
Product Name |
Information |
| PC-25480 |
Stafori-2
STAT4 inhibitor
|
Stafori-2 is the phosphate analog of Stafori-1 and potent, selective small molecule inhibitor of STAT4 Src homology 2 domain with Ki of 0.18 uM in FP assays, shows good selectivity over other STAT family members. |
| PC-25392 |
Colivelin TFA
STAT3 agonist
|
Colivelin TFA is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. |
| PC-25391 |
Colivelin
STAT3 agonist
|
Colivelin is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. |
| PC-25382 |
Brevilin A
STAT3 inhibitor, LRRC15 inhibitor
|
Brevilin A is an orally active STAT3/JAK inhibitor with IC50 of 10.6 uM (STAT3), exerts potent anti-inflammatory, antitumor, immunosuppressive, and anti-liver fibrosis effects, also reduces protein levels of LRRC15 in RA fibroblast-like synoviocytes (RA-FLSs). |
| PC-25257 |
WR-S-462
STAT3 inhibitor
|
WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction. |
| PC-25251 |
LZJ66
STAT3 inhibitor
|
LZJ66 (STAT3-IN-20, Compound 40) is a potent, selective STAT3 inhibitor, inhibits L-6/JAK/STAT3 signaling pathway with IC50 of 0.65 uM. |
| PC-25250 |
STAT3 inhibitor W36
STAT3 inhibitor
|
STAT3 inhibitor W36 is a potent, selective STAT3 inhibitor with SPR KD of 323.3 nM, inhibits IL-6/JAK/STAT3 signaling pathway with IC50 of 0.87 uM in HEK-Blue-IL-6 cell model. |
| PC-24939 |
STAT3 inhibitor YZ-35
STAT3 inhibitor
|
STAT3 inhibitor YZ-35 is potent, selective STAT3 inhibitor with binding Kd of 190 nM in ITC assays amd Ki of 380 nM in FP assays. |
| PC-24629 |
PMM-172
STAT3 inhibitor
|
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM. |
| PC-24623 |
RDp002
STAT3 inhibitor
|
RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues. |
| PC-24431 |
STAT3 inhibitor K116
STAT3 inhibitor
|
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines. |
| PC-24308 |
Hygromycin B
CHI3L1-STAT3 inhibitor
|
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells, also an inhibitor of the STAT3-CCD domain, disrupts the CHI3L1-STAT3 interaction, inhibits glioblastoma both in vitro and in vivo. |
