| Cat. No. |
Product Name |
Information |
| PC-43223 |
EHop-016
Rac inhibitor
|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 uM, which is 100-fold lower than for NSC23766, EHop-016 is specific for Rac1 and Rac3 at <5 uM. |
| PC-43180 |
ML141
Cdc42 inhibitor
|
ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras. |
| PC-43137 |
Y16
RhoA-LARG inhibitor
|
Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM. |
| PC-43133 |
Rhosin
RhoA inhibitor
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
| PC-43132 |
Rhosin hydrochloride
RhoA inhibitor
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
| PC-62792 |
BQU-057
GTPase Ral inhibitor
|
BQU-057 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 2.2 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay.. |
| PC-62791 |
BQU-082
GTPase Ral inhibitor
|
BQU-082 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 1.7 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay. |
| PC-62562 |
TBOPP
DOCK1 inhibitor
|
TBOPP is a selective inhibitor of Rac-specific guanine nucleotide exchange factor DOCK1, inhibits DOCK1-mediated Rac activation with IC50 of 8.4 uM. |
| PC-62515 |
Rheb inhibitor NR1
Rheb inhibitor
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
| PC-62450 |
CPYPP
DOCK2-Rac1 inhibitor
|
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction. |
| PC-62448 |
Phox-I1
p67phox-Rac1 inhibitor
|
Phox-I1 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=100 nM) and interferes with Rac1-GTP interaction with p67phox. |
| PC-62365 |
ML282
Rab7 inhibitor
|
ML282 (CID 1067700) is a competitive small molecule inhibitor of nucleotide binding by Ras-related GTPases, binds the nucleotide binding pocket of Rab7 with Ki value of 13 nM. |
