| Cat. No. |
Product Name |
Information |
| PC-49212 |
EHT1864
Rac inhibitor
|
EHT1864 is a small molecule Rac inhibitor that blocks the Rac1 signaling pathways with IC50 of 5 uM in cellular luciferase assays, binds to Rac1b and Rac2 with very similar affinities (50 and 60 nM, respectively). |
| PC-38721 |
1D-142
RAC1 inhibitor
|
1D-142 is a novel small molecule RHO family of GTPase RAC1 inhibitor, inhibits Rac1-GEF interaction and reduces Rac1-mediated TNFα-induced NF-κB nuclear translocation during cell proliferation and migration. |
| PC-38507 |
RBC10
Ral GTPase inhibitor
|
RBC10 is a small molecule that target the Ral GTPase, inhibits Ral binding to its effector RalBP1, Ral-mediated cell spreading in murine fibroblasts and anchorage-independent growth of human cancer cell lines. |
| PC-38415 |
ARN22089
Cdc42 inhibitor
|
ARN22089 (ARN 22089) is a specific small molecule inhibitor of putative CDC42 family effector interaction, binds to CDC42 and has broad anti-cancer activity and inhibits MAPK and S6 signaling. |
| PC-36078 |
Bragsin2
BRAG2 inhibitor
|
Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
| PC-36077 |
Bragsin1
BRAG2 inhibitor
|
Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
| PC-63530 |
ML099
Rho-family GTPases activator
|
ML099 (CID888706) is a small molecule, pan activator of Rho-family GTPases, activates Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A |
| PC-63241 |
Z62954982
Rac1 inhibitor
|
Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM). |
| PC-43277 |
CASIN
Cdc42 inhibitor
|
CASIN is a specific inhibitor of small RhoGTPase Cdc42, inhibits PIP2-stimulated actin polymerization in Xenopus egg extracts with IC50 of 2 uM. |
| PC-43278 |
BQU57
Ral inhibitor
|
BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively. |
| PC-43276 |
RBC8
GTPase Ral inhibitor
|
RBC8 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 3.5 and 3.4 uM, respectively. |
| PC-43223 |
EHop-016
Rac inhibitor
|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 uM, which is 100-fold lower than for NSC23766, EHop-016 is specific for Rac1 and Rac3 at <5 uM. |
