Cat. No. |
Product Name |
Information |
PC-49214 |
CS7171
Rac1 inhibitor
|
CS7171 is an effective, blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
PC-49213 |
JKF-034
Rac1 inhibitor
|
JKF-034 is an effective,blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
PC-49212 |
EHT1864
Rac inhibitor
|
EHT1864 is a small molecule Rac inhibitor that blocks the Rac1 signaling pathways with IC50 of 5 uM in cellular luciferase assays, binds to Rac1b and Rac2 with very similar affinities (50 and 60 nM, respectively). |
PC-43278 |
BQU57
GTPase Ral inhibitor
|
BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively. |
PC-43276 |
RBC8
RalGTPase Ral inhibitor
|
RBC8 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 3.5 and 3.4 uM, respectively. |
PC-62562 |
TBOPP
DOCK1 inhibitor
|
TBOPP is a selective inhibitor of Rac-specific guanine nucleotide exchange factor DOCK1, inhibits DOCK1-mediated Rac activation with IC50 of 8.4 uM. |
PC-62515 |
Rheb inhibitor NR1
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
PC-61174 |
SecinH3
small GEFs inhibitor
|
SecinH3 is a selective inhibitor of small GEFs of the cytohesin family, blocks human, mouse and Drosophila cytohesins with IC50 of 2.4 to 5.6 uM. |
PC-60905 |
MBQ-167
Rac/Cdc42 inhibitor
|
MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells. |
PC-60847 |
Nexinhib 20
|
Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors. |
PC-60611 |
NAV 2729
ARF6 inhibitor
|
NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays. |
PC-44661 |
NSC 23766 trihydrochloride
|
NSC 23766 trihydrochloride is a specific small molecule inhibitor of Rac GTPase. |