| Cat. No. |
Product Name |
Information |
| PC-20089 |
MRT-92
Smoothened inhibitor
|
MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM. |
| PC-38710 |
Sonidegib phosphate
Smoothened inhibitor
|
Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. |
| PC-38709 |
Sonidegib
Smoothened inhibitor
|
Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. |
| PC-62438 |
ALLO-2
|
ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. |
| PC-62202 |
22-Azacholesterol
|
22-Azacholesterol is the first small molecule inhibitor that inhibits Hedgehog (Hh) signaling by binding the oxysterol-binding site of Smo, inhibits Sonic Hedgehog (Shh) signaling with IC50 of 3 uM in NIH-3T3 cells.. |
| PC-62201 |
20(S)-Hydroxycholesterol
|
20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site. |
| PC-62181 |
BRD6851
|
BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist. |
| PC-62177 |
ALLO-1
|
ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM). |
| PC-62174 |
MRT-83 hydrochloride
|
MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM. |
| PC-62172 |
GSA-10
|
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
| PC-61758 |
LEQ 506
|
LEQ 506 (NPV-LEQ 506) is a second-generation inhibitor of Smoothened (Smo) with IC50 of 2 nM and 4 nM for human and mouse Smo, respectively. |
| PC-60380 |
IHR-1
|
A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay. |
