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Request The Product List ofThyroid Hormone Receptor (THR) Thyroid Hormone Receptor (THR)

Cat. No. Product Name Information
PC-20362

Sobetirome

TRβ1 agonist

QRX-431 (Thyromimetic GC-1, Sobetirome, QRX431) is a TRβ1-selective thyromimetic, selectively binds to TRβ over TRα with Kd values of 0.1 and 1.8 nM, respectively.
PC-20361

CS27109

THR-β agonist

CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.
PC-38128

DCZ0415

TRIP13 inhibitor

DCZ0415 (DCZ-0415) is a small-molecule inhibitor targeting thyroid hormone receptor interacting protein 13 (TRIP13) with Kd of 2.42 uM in SPR assay.
PC-38030

VK2809

THRβ agonist

VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
PC-35610

KB-141

THR-β agonist

KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ (THR-β) agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.
PC-42920

MGL-3196

THR-β agonist

MGL-3196 (VIA-3196, Resmetirom) is a potent and highly selective agonist of THR-β (Thyroid Hormone Receptor β) with EC50 of 0.21 uM.
PC-24498

TRβ agonist IS25

TRβ agonist

TRβ agonist IS25 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ) with EC50 of 458 nM, weakly activates TRα to 30% at 1 uM.
PC-24497

TRβ agonist TG68

TRβ agonist

TRβ agonist TG68 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ), the prodrug of IS25 (TRβ, EC50=458 nM), promotes lipolysis through the activation of AMPK/ACC pathway.
PC-24488

ZTA-261

THRβ agonist

ZTA-261 is a thyroid hormone analog and selective agonist agonist of thyroid hormone receptor beta-subtype (TRβ, THRβ) with IC50 of 6.3 nM, >100-fold selective over TRα.
PC-24487

Eprotirome

THRβ agonist

Eprotirome (KB-2115) is a liver-specific thyromimetic and thyroid hormone receptor-beta (TRβ) agonist with modestly higher affinity for TRβ than for TRα, reduces serum cholesterol independent of the LDL receptor.
PC-24184

Simedeutirom

THR-β agonist

Simedeutirom is a potent, selective thyroid hormone receptor agonist with EC50 of 0.1-1 uM.
PC-24128

ABX-002

THR-β agonist

Elunetirom (ABX-002, MA-JD21) is a potent, selective, CNS-permeable, thyromimetic thyroid hormone receptor beta (THR-β) agonist.

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