| Cat. No. |
Product Name |
Information |
| PC-21818 |
DSP-0509
TLR7 agonist
|
DSP-0509 (DSP0509) is a potent selective small-molecule TLR7 agonist with EC50 of 515 nM and 33 nM in cells expressing human and murine TLR7, respectively. |
| PC-21372 |
TH1020
TLR5 antagonist
|
TH1020 is a potent, selective antagonist of TLR5/flagellin protein-protein interaction with IC50 of 0.85 uM. |
| PC-21010 |
E6742
TLR7/TLR8 inhibitor
|
E6742 (E6742) is a potent, selective, dual TLR7/8 inhibitor with binding Kd of 1.7 uM/37 nM in ITC assays, respectively, inhibits TLR7/8 agonist CL097 induced reporter activation with IC50 values of 22, 68, and 3.0 nM for hTLR7, mTLR7, and hTLR8, respectively. |
| PC-20815 |
MHV370
TLR7/8 inhibitor
|
MHV370 (MHV-370) is a potent, selective, orally bioavailable inhibitor of Toll-like receptors 7 and 8 (TLR7/8) with IC50 of 1.1 and 4.5 nM in cell-based assays. |
| PC-20737 |
Neoseptin-3
TLR4/MD2 agonist
|
Neoseptin-3 is a specific synthetic agonist of mouse toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex, promotes macrophage TNFα production with EC50 of 18.5 uM. |
| PC-20231 |
CU-CPT17e
TLR agonist
|
CU-CPT17e is a multi-TLR agonist withEC50 of 4.8 μM, 13.4 μM and 5.7 μM for strong NF-κB activation on hTLR 3, 8 and 9 respectively. |
| PC-20229 |
AZD8848
TLR7 agonist
|
AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5. |
| PC-20228 |
TL8-506
TLR8 agonist
|
TL8-506 is a potent, selective TLR8 agonist with EC50 of 30 nM for inducing NF-κB activation in TLR8-transfeceted HEK293 cells. |
| PC-20226 |
DSR-6434
TLR7 agonist
|
DSR-6434 (DSR6434) is a highly potent, specific TLR7 agonist with EC50 of 7.2 nM (hTLR7) and 4.6 nM (mTLR7) for stimulating reporter gene activity in HEK293 cells expressing TLR7. |
| PC-49254 |
GS-9620
TLR7 agonist
|
Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7 (TLR7) with EC50 of 291 nM. |
| PC-49146 |
SZU-106
TLR7 agonist
|
SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway. |
| PC-49145 |
SZU-101
TLR7 agonist
|
SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling. |
