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Chemical Structure : IACS-010759
CAS No.: 1570496-34-2
Catalog No.: PC-35205Not For Human Use, Lab Use Only.
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain.
IACS-010759 decreases cell viability and increases apoptosis with EC50 values between 1 nM-50 nM across multiple lines.
IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, reduces aspartate production that leads to impaired nucleotide biosynthesis.
IACS-010759 potently inhibits tumor growth of brain cancer and AML in vivo.
| M.Wt | 562.568 | |
| Formula | C25H25F3N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole |
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1. Molina JR, et al. Nat Med. 2018 Jun 11. doi: 10.1038/s41591-018-0052-4.
2. Vangapandu HV, et al. Oncotarget. 2018 May 18;9(38):24980-24991.
3. Lissanu Deribe Y, et al. Nat Med. 2018 Jun 8. doi: 10.1038/s41591-018-0019-5.
4. Jennifer Molina, et al. Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors. AACR. DOI: 10.1158/1538-7445.
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