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Cat. No. Product Name Information
PC-20502

JS-017

A2E degrader

JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM.
PC-49727

YTK-2205

p62 agonist, autophagy inducer

YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation.
PC-49174

EAD1

Autophagy inhibitor

EAD1 is a potent autophagy inhibitor, exhibits growth inhibitory activity in human cancer cell lines, H460 and HCC827 NSCLC and BxPC3 pancreatic cancer cells with IC50 of 11, 7.6, and 5.8 uM, respectively.
PC-38562

Autophagy inducer D61

Autophagy inducer

Autophagy inducer D61 is a small molecule autophagy inducer with antibacterial activity, induces LC3II and promotes aggregation of LC3II near Salmonella.
PC-73084

Autogramin-1

Autophagy inhibitor

Autogramin-1 is a potent autophagy inhibitor, inhibits autophagy induced by either starvation or mTORC1 inhibition with IC50 of 0.17 and 0.44 uM, respectively.
PC-73072

LCC03

Autophagy inducer

LCC03 is a salicylanilide derivative and autophagy inducer, dose-dependently suppresses proliferation and retarded cell-cycle progression in CRPC cells (IC50, 0.69 to 4.8 uM).
PC-73004

Autophagy inhibitor EACC

Autophagy inhibitor

Autophagy inhibitor EACC (EACC) is a novel small molecule, reversible inhibitor of autophagy, inhibits autophagic flux by blocking autophagosomelysosome fusion.
PC-72988

Autophagy activator EN6

Autophagy activator

Autophagy activator EN6 (EN6) is a small-molecule in vivo activator of autophagy, covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase (vacuolar H+-ATPase).
PC-72715

Autophazole

Autophagy inhibitor

Autophazole is a novel autophagy inhibitor, promotes cancer cell death via caspase activation.
PC-72653

DC-LC3in-D5

LC3 Protein modulator

DC-LC3in-D5 is a small molecule covalent modulator of LC3A/B and autophagy inhibitor, binds to LC3B and covalently modifies Lysine 49.
PC-72577

CBK288679

Autophagy inhibitor

CBK288679 (CBK79) is a novel compound that impairs both protein degradation by the ubiquitin-proteasome system (UPS) and autophagy.
PC-38229

Autoquin

Autophagy inhibitor

Autoquin is a novel autophagy inhibitor (IC50=0.56 uM) by indirect modulation of the activity of the lysosomal enzymes acid sphingomyelinase and acid ceramidase.

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