| Cat. No. |
Product Name |
Information |
| PC-49682 |
NSC232003
UHRF1 inhibitor
|
NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation. |
| PC-49681 |
UF146
UHRF1 inhibitor
|
UF146 (UF-146) is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1 with KD of 3.71 uM, significantly inhibits the binding of UHRF1 and hemi-methylated DNA with IC50 of 499.4 nM in FRET assays. |
| PC-73377 |
GSK3543105
DNMT1 inhibitor
|
GSK3543105 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 33 nM. |
| PC-72249 |
5A-DMP
UHRF1 inhibitor
|
5A-DMP is a novel TTD-binding compound that binds to tandem Tudor domain (TTD) of UHRF1, inhibits the full-length UHRF1: LIG1 interaction in Xenopus egg extracts. |
| PC-72246 |
GSK3482364
DNMT1 inhibitor
|
GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM). |
| PC-72245 |
GSK3484862
DNMT1 inhibitor
|
GSK3484862 (GSK-3484862) is a selective, non-covalent inhibitor of DNMT1, potently inhibits DNMT1 enzymatic activity with IC50 of 0.23 uM. |
| PC-72244 |
GSK3685032
DNMT1 inhibitor
|
GSK3685032 (GSK-3685032) is a potent, first-in-class, highly selective DNMT1 inhibitor with IC50 of 36 nM, >2,500-fold over DNMT3A/3L and DNMT3B/3L. |
| PC-38285 |
STM2457
METTL3 inhibitor
|
STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM. |
| PC-36114 |
Bobcat339
TET inhibitor
|
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| PC-35290 |
MC3343
DNMT inhibitor
|
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively. |
| PC-35122 |
NV03
UHRF1 inhibitor
|
NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM. |
| PC-35121 |
NV01
UHRF1 inhibitor
|
NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM. |
