| Cat. No. |
Product Name |
Information |
| PC-23736 |
USP30-I-1
USP30 inhibitor
|
USP30-I-1 is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs. |
| PC-23143 |
IsoLiPro
USP11 inhibitor
|
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination. |
| PC-23140 |
LN-439A
BAP1 inhibitor
|
LN-439A is a small molecule BRCA1-associated protein 1 (BAP1) inhibitor by binding to the catalytic pocket of BAP1, leading to the ubiquitination and degradation of Krüppel-like factor 5 (KLF5), inhibits proliferation and migration of BLBC cells. |
| PC-23076 |
FX-171-C
BRISC inhibitor
|
FX-171-C is a specific, small molecule inhibitor Zn2+-dependent JAMM/MPN deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC) with IC50 of 1.4 uM. |
| PC-23075 |
JMS-175-2
BRISC inhibitor
|
JMS-175-2 is a specific, small molecule inhibitor Zn2+-dependent JAMM/MPN deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC) with IC50 of 3.8 uM. |
| PC-22953 |
MS5105
OTUB1 ligand
|
MS5105 is a small molecule OTUB1-covalent ligand, display improved effectiveness in covalently modifying OTUB1 compared with EN523, is useful for DUBTAC design. |
| PC-22885 |
USP7 inhibitor X36
USP7 inhibitor
|
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47. |
| PC-22878 |
FLX4
USP7 inhibitor
|
FLX4 is a potent, selective and allosteric inhibitor of USP7 with IC50 of <1 uM. |
| PC-22877 |
YCH3124
USP7 inhibitor
|
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25. |
| PC-22864 |
USP1 inhibitor C527
USP1 inhibitor
|
USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex). |
| PC-22863 |
Zerumbone
TAGLN/USP1 inhibitor
|
Zerumbone is a natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet with anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity, binds to transgelin (TAGLN) and reduces the retention of USP1 in the cytoplasm and the degradation of ZEB1 ubiquitination. |
| PC-22320 |
Compound 7695-0983
FAT10 inhibitor
|
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy. |
