| Cat. No. |
Product Name |
Information |
| PC-43555 |
P50429
USP7/USP47 inhibitor
|
P50429 (P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs. |
| PC-45339 |
HBX 19818
USP7 inhibitor
|
HBX 19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM. |
| PC-45856 |
USP8-IN-22d
USP8 inhibitor
|
USP8-IN-22d is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM. |
| PC-45857 |
USP8-IN-22c
USP8 inhibitor
|
USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM. |
| PC-45056 |
USP7-IN-1
USP7 inhibitor
|
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM. |
| PC-46007 |
SJB3-019A
USP1 inhibitor
|
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. |
| PC-27978 |
Hemi-ubistatin
Ubiquitin-proteasome system inhibitor
|
Hemi-ubistatin B (h-ubiB) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, penetrates cancer cells and alters the cellular ubiquitin landscape. |
| PC-27904 |
USP15 inhibitor Z86
USP15 inhibitor, Wnt inhibitor
|
USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4. |
| PC-26833 |
SGC-UBD1031
USP16/HDAC6-UBD inhibitor
|
SGC-UBD1031 (UBD1031) is a potent, specific dual USP16 and HDAC6 zinc-finger ubiquitin-binding domain (UBD) with SPR Kd of 48 nM and 16 nM respectively, disrupts the interaction between the C-terminus of ISG15 and USP16-UBD, as well as the interaction between ISG15 and HDAC6-UBD with IC50 of 1.7 uM and 1.5 uM in cellular assays. |
| PC-26806 |
NK192
USP7 inhibitor
|
NK192 is a potent, selective USP7 inhibitor with IC50 of 20 nM, shows proteome-wide specificity. |
| PC-26791 |
ZHAWOC8655
USP18 inhibitor
|
ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15. |
| PC-26670 |
Berberine chloride
USP22 inhibitor
|
Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation. |
