Cat. No. |
Product Name |
Information |
PC-20184 |
GSK2643943A
USP20 inhibitor
|
GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho). |
PC-20004 |
TG2-179-1
BAP1 inhibitor
|
TG2-179-1 is a potent, selective and covalently inhibitor of deubiquitinase (DUB) BRCA1-associated protein-1 (BAP1), covalently binds to the active site of BAP1 (Cys91), exhibits potent cytotoxic activity against colon cancer cells. |
PC-49744 |
BML-260
JSP-1 (DUSP22) inhibitor
|
BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes. |
PC-49626 |
8RK64
UCHL1 inhibitor
|
8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5. |
PC-49546 |
Usp22i-S02
USP22 inhibitor
|
Usp22i-S02 (Usp22 inhibitor S02) is a specific small-molecule inhibitor of the Foxp3-specific deubiquitinase USP22, down-regulates Foxp3 expression in Treg cells in a Usp22- but not Usp21-dependent manner. |
PC-38585 |
USP10 inhibitor Wu-5
USP10 inhibitor
|
USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells. |
PC-73354 |
USP inhibitor 2
USP4 inhibitor
|
USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM). |
PC-73353 |
USP inhibitor 1
USP33 inhibitor
|
USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition. |
PC-73318 |
KSQ4279
USP1 inhibitor
|
KSQ4279 (KSQ-4279) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2. |
PC-73197 |
SJB2-043
USP1 inhibitor
|
SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM. |
PC-73132 |
6RK73
UCHL1 inhibitor
|
6RK73 is a potent, specific and covalent UCHL1 inhibitor with IC50 of 0.23 uM. |
PC-72534 |
USP8 inhibitor RA-9
USP8 inhibitor
|
USP8 inhibitor RA-9 is a small molecule USP8 inhibitor. |