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Cat. No. Product Name Information
PC-20914

BMS-502

Dual DGKα/ζ inhibitor

BMS-502 (BMS 502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
PC-20666

BAY 2965501

DGK zeta inhibitor

BAY2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill.
PC-38842

JNJ-3790339

DGKα inhibitor

JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin.
PC-63497

CU-3

DGKα inhibitor

CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.
PC-70274

R 59022

DGK inhibitor

R 59022 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets.
PC-21532

BMS-332

Dual DGKα/ζ inhibitor

BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.
PC-21287

BMS-684

DGKα inhibitor

BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.
PC-21185

Atractylenolide II

DGKQ activator

Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
PC-70275

R-59949

A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.

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