Cat. No. |
Product Name |
Information |
PC-35958 |
HOIPIN-1
HOIP inhibitor
|
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.. |
PC-35913 |
HS-152
SMURF1 inhibitor
|
HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively). |
PC-63515 |
BI8626
HUWE1 inhibitor
|
BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM). |
PC-63514 |
BI8622
HUWE1 inhibitor
|
BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b). |
PC-63321 |
BRD5529
CARD9-TRIM62 inhibitor
|
BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM. |
PC-62453 |
Skp2-IN-C1
Skp2 inhibitor
|
Skp2-IN-C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. |
PC-62313 |
Tasisulam
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
PC-62312 |
Tasisulam sodium
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
PC-61670 |
BC-1485
FIEL1 inhibitor
|
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination. |
PC-61253 |
DT204
SCFSkp2 inhibitor
|
DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis. |
PC-61192 |
SCF-I2
SCFCdc4 inhibitor
|
SCF-I2 is an allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assays. |
PC-60879 |
BC-1215
Fbxo3 inhibitor
|
BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL. |