| Cat. No. |
Product Name |
Information |
| PC-25377 |
A5-MMC17
FBW7 modulator
|
A5-MMC17 is a specific, small molecule allosteric modulator of FBW7 E3 ligase with MST Kd of 45 uM, targets FBW7-pocket G, induces proteasome- and Cullin-RING-dependent c-MYC and c-JUN degradation in cells. |
| PC-24933 |
DDO-4033
SPOP inhibitor
|
DDO-4033 is a potent, selective E3 ligase speckle-type POZ protein (SPOP) inhibitor with IC50 of 16.48 uM, binds to SPOP-MATH with Kd of 15.1 uM in MST assay. |
| PC-24421 |
PRLX-93936
NPC molecular glue degrader
|
PRLX-93936 is a molecular glue that binds to and reprograms the TRIM21 ubiquitin ligase, causes TRIM21 to bind the nuclear pore protein NUP98, triggering nuclear pore complex (NPC) degradation. |
| PC-24401 |
GH501
Skp1-Skp2 inhibitor
|
GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF). |
| PC-24059 |
Lanatoside C
DENV inhibitor, FOXP3 inhibitor
|
Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1, directly binds the E3 ligase STUB1 (ITC, Ka=13 uM). |
| PC-23661 |
Y043-4427
DTX2 inhibitor
|
Y043-4427 (mDTX2i, C22H24N4O2) is a potent small molecule inhibitor of Deltex E3 ubiquitin ligase 2 (DTX2) with IC50 of 30.83 uM in Hepa1-6 cells. |
| PC-23528 |
iBFAR2
BFAR inhibitor
|
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice. |
| PC-22133 |
LS-102
Synoviolin inhibitor
|
LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM. |
| PC-21791 |
MN714
SOCS2 inhibitor
|
MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2). |
| PC-21790 |
MN551
SOCS2 inhibitor
|
MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate. |
| PC-21767 |
AAA-237
Skp2 inhibitor
|
AAA-237 (SCFSkp2-IN-2) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells. |
| PC-21766 |
Smurf1 inhibitor A01
Smurf1 inhibitor
|
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level. |
