| Cat. No. |
Product Name |
Information |
| PC-60518 |
CC-220
E3 ubiquitin ligase modulator
|
Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM. |
| PC-45731 |
PRT4165
PRC1 inhibitor
|
PRT4165 (NSC 600157) is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8. |
| PC-46931 |
Suramin sodium salt
Cullin-RING E3 ubiquitin ligase inhibitor
|
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34. |
| PC-42099 |
SZL P1-41
Skp2 inhibitor
|
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
| PC-26625 |
NSC689857
Skp2 inhibitor
|
NSC689857 is a potent EGFR and ubiquitin E3 ligase SCFSKP2 inhibitor with IC50 value of 36 uM for Skp2-Cks1 interaction, inhibit p27 ubiquitylation with IC50 of 30 uM. |
| PC-26463 |
NX-1013
Cbl-b inhibitor
|
NX-1013 is a small-molecule inhibitor of the Casitas B-lineage lymphoma-b (Cbl-b) E3 ubiquitin ligaseE3 ubiquitin ligase, dissects the role of EGFR ubiquitination in its endocytic trafficking and signaling. |
| PC-26049 |
GSR-3-120
c-Cbl inhibitor
|
GSR-3-120 (Compound 3-120) is a specific small molecule inhibitor / antagonist of E3 ubiquitin ligase c-Cbl, inhibits EGFR binding to CBL family proteins and competes with phosphotyrosine 1045 of the EGFR for binding to c-Cbl. |
| PC-25921 |
XZA-1
HADH activator, CBX4 inhibitor
|
XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation. |
| PC-25785 |
Cbl-b-IN-1
Cbl-b inhibitor
|
Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL. |
| PC-25779 |
PF-G23
Cbl-b inhibitor
|
PF-G23 (CBL-B inhibitor G23) is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), shows binding selectivity over C-CBL. |
| PC-25778 |
HST-1011
Cbl-b inhibitor
|
HST-1011 is a potent, selective, orally bioavailable allosteric small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), robustly increases anti-tumor immunity in vitro and in vivo. |
| PC-25777 |
Cbl-b inhibitor 10
Cbl-b inhibitor
|
Cbl-b inhibitor 10 is a potent and orally bioavailable Casitas B-lineage lymphoma-b (CBLB, Cbl-b) inhibitor with biochemical IC50 of 9.1 nM, and EC50 of 180.6 nM in IL-2 secretion assays. |
