| Cat. No. |
Product Name |
Information |
| PC-24933 |
DDO-4033
SPOP inhibitor
|
DDO-4033 is a potent, selective E3 ligase speckle-type POZ protein (SPOP) inhibitor with IC50 of 16.48 uM, binds to SPOP-MATH with Kd of 15.1 uM in MST assay. |
| PC-24781 |
NEDD4 inhibitor 32
NEDD4 inhibitor
|
NEDD4 inhibitor 32 is a selective, covalent inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination. |
| PC-24708 |
Skp2 inhibitor E35
Skp2 inhibitor
|
Skp2 inhibitor E35 (HK-E35) is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 4.8 uM against Skp2-Cks1 binding. |
| PC-24707 |
Skp2 inhibitor 10h
Skp2 inhibitor
|
Skp2 inhibitor 10h is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 0.38 uM against Skp2-Cks1 binding. |
| PC-24706 |
ZK-14i
Skp2 inhibitor
|
ZK-14i (Skp2 inhibitor 14i) is a potent inhibitor of S-phase kinase-associated protein 2 (Skp2) with IC50 of 2.8 uM against the Skp2-Cks1 interaction. |
| PC-24524 |
GS143
E3 ligase β-TrCP inhibitor
|
GS143 is a specific small molecule inhibitor of E3 ligase β-TrCP, exhibits potent latency reversing agent (LRA) activity, also is a NF-kappaB signaling inhibitor, inhibits IκBα ubiquitylation (IC50=5.2 uM). |
| PC-24059 |
Lanatoside C
DENV inhibitor, FOXP3 inhibitor
|
Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1, directly binds the E3 ligase STUB1 (ITC, Ka=13 uM). |
| PC-23887 |
Hakin-1
Hakai inhibitor
|
Hakin-1 (Hakai inhibitor-1) is a specific small molecule inhibitor of the E3 ubiquitin-ligase Hakai, reduces Hakai-mediated total ubiquitination and Hakai-mediated ubiquitination of E-cadherin. |
| PC-23661 |
Y043-4427
DTX2 inhibitor
|
Y043-4427 (mDTX2i, C22H24N4O2) is a potent small molecule inhibitor of Deltex E3 ubiquitin ligase 2 (DTX2) with IC50 of 30.83 uM in Hepa1-6 cells. |
| PC-22789 |
BC-1293
FBXO24 inhibitor
|
BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties. |
| PC-22418 |
PFI-E3H1
GID4 inhibitor
|
PFI-E3H1 is a potent, selective chemical handle of Gid4 subunit of the human E3 ligase CTLH degradation complex with IC50 of 2.5 uM in NanoBRET assay measuring the Gid4/MPGLWKS interaction. |
| PC-22417 |
PFI-7
GID4 inhibitor
|
PFI-7 is a potent, selective and cell-active chemical probe inhibitor for GID4, a substrate-binding receptor within the C-terminal to LisH (CTLH) E3 ligase complex. |
