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Request The Product List ofE3 Ubiquitin Ligase E3 Ubiquitin Ligase

Cat. No. Product Name Information
PC-60547

BC-1382

HECTD2 inhibitor

BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.
PC-60518

CC-220

E3 ubiquitin ligase modulator

Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM.
PC-45731

PRT-4165

PRC1 inhibitor

PRT-4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8.
PC-46931

Suramin sodium salt

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity.
PC-42180

Avadomide

Avadomide (CC-122) is a small molecule that binds to cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in DLBCL and T cells in vitro and in vivo.
PC-42099

SZL P1-41

Skp2 inhibitor

SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
PC-21791

MN714

SOCS2 inhibitor

MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2).
PC-21790

MN551

SOCS2 inhibitor

MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate.
PC-21767

AAA237

Skp2 inhibitor

AAA-237 (AAA237) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells.
PC-21766

Smurf1 inhibitor A01

Smurf1 inhibitor

Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level.
PC-21555

C7683

Cbl-b inhibitor

C7683 is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC5 of <1 nM, an analogue of Nx-1607.
PC-21554

Nx-1607

Cbl-b inhibitor

Nx-1607 is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b.

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