| Cat. No. |
Product Name |
Information |
| PC-21794 |
eEF2K degrader C1
eEF2K inhibitor
|
eEF2K degrader C1 is a small‐molecule degrader of eEF2K, acts a molecular glue to enhance the interaction of eEF2K with the ubiquitin E3 ligase βTRCP, thereby promoting the proteasomal degradation of eEF2K. |
| PC-21688 |
MG-002
eIF4A inhibitor
|
MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM. |
| PC-21264 |
Briciclib
eIF4E inhibitor
|
Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6). |
| PC-20686 |
SBI-0498
eIF4F inhibitor
|
SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20685 |
SBI-5844
eIF4F inhibitor
|
SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20483 |
eIF4E-RBM38 inhibitor 094
eIF4E-RBM38 inhibitor
|
eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners. |
| PC-72482 |
Rohinitib
eIF4A1 inhibitor
|
Rohinitib is a potent and specific inhibitor of eIF4A1, inhibits growth and survival of AML cells especially cells with FLT3-ITD. |
| PC-35162 |
Elatol
|
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. |
| PC-62424 |
eIF4A3-IN-2
|
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases. |
| PC-70179 |
NH-125
|
A potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells. |
| PC-60161 |
eIF4A3-IN-1q
|
A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM. |
| PC-42237 |
4E2RCat
|
A small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay. |
