| Cat. No. |
Product Name |
Information |
| PC-27485 |
Odemsertib
IRAK inhibitor
|
Odemsertib is a potent, selective IRAK inhibitor. |
| PC-25433 |
GLPG4471
IRAK4 inhibitor
|
GLPG4471 (GLPG-4471) is a a potent and selective IRAK4 inhibitor with IC50 of 1.7 nM, potently inhibits CL097-induced TNFα in PBMCs with IC50 of 39.4 nM. |
| PC-22433 |
TCS2210
IRAK1 inhibitor
|
TCS2210 (TCS 2210) is a selective inhibitor of IRAK1 (SPR Kd=1.76 uM) and inducer of neuronal differentiation in mesenchymal stem cells, suppresses the growth of epithelial ovarian cancer (EOC) cells. |
| PC-22269 |
Edecesertib
IRAK4 inhibitor
|
Edecesertib (GS-5718) is a potent, selective, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 0.6 nM. |
| PC-22268 |
BIO-8169
IRAK4 inhibitor
|
BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays. |
| PC-21921 |
BIO-7488
IRAK4 inhibitor
|
BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP). |
| PC-21202 |
KME-3859
IRAK4 inhibitor
|
KME-3859 is a potent, selective IRAK4 inhibitor with IC50 of 5 nM, 100-fold selective over IRAK1. |
| PC-21201 |
KME-2780
IRAK1/4 inhibitor
|
KME-2780 (KME2780) is a potent and selective dual IRAK1 and IRAK4 (IRAK1/4) inhibitor with IC50 of 19 and 0.5 nM, respectively. |
| PC-49845 |
GLPG2534
IRAK4 inhibitor
|
GLPG2534 (GLPG 2534) is a potent, selective IRAK4 inhibitor with therapeutic potential in chronic inflammatory skin diseases. |
| PC-49046 |
ND-2110
IRAK4 inhibitor
|
ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM). |
| PC-38684 |
BAY1830839
IRAK4 inhibitor
|
BAY1830839 is a potent, selective IRAK4 inhibitor with IC50 of 3.0 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway. |
| PC-38683 |
Zabedosertib
IRAK4 inhibitor
|
Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway. |
