| Cat. No. |
Product Name |
Information |
| PC-72650 |
NCATS-SM5637
mutant IDH1 inhibitor
|
NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively. |
| PC-38189 |
DS-1001b
mutant IDH1 inhibitor
|
DS-1001b (DS1001b) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants. |
| PC-38188 |
DS-1001b free base
mutant IDH1 inhibitor
|
DS-1001b free base (DS1001b, Safusidenib) is a potent, selective, BBB-permeable and orally bioavailable mutant IDH1 inhibitor with IC50 of 8.4/11 nM against IDH1 R132H/R132C mutants. |
| PC-35975 |
Olutasidenib
mutant IDH1 inhibitor
|
Olutasidenib (FT-2102) is a potent, orally bioavailable, brain penetrant, and selective mIDH1 inhibitor with IC50 of 21.2 nM and 114 nM for IDH1 mutant R132H and R132C, respectively. |
| PC-35173 |
IDH889
mutant IDH1 inhibitor
|
IDH889 (IDH-889) is a potent, selective, brain penetrant, orally active IDH1 R132H mutant with IC50 of 20 nM, with good overall selectivity vs the wt IDH1. |
| PC-60534 |
Vorasidenib
mutant IDH1/2 inhibitor
|
Vorasidenib (AG-881) is a potent, oral, brain-penetrant dual inhibitor of mIDH1 and mIDH2 with IC50 of 6 nM and 12 nM for IDH1-R132H and IDH2-R140Q, respectively. |
| PC-60292 |
BAY-1436032
|
BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively. |
| PC-60164 |
IDH305
|
IDH 305 (IDH305) is a potent, selective, brain penetrant mutant IDH1 inhibitor with IC50 of 18 and 28 nM for IDH1 R132H and R132C. |
| PC-45645 |
GSK-864
|
GSK-864 is a compound structurally related to GSK321 with improved in vivo pharmacokinetic properties. |
| PC-45529 |
Enasidenib
mutant IDH2 inhibitor
|
Enasidenib (AG-221, CC-90007) is an orally available, selective, potent inhibitor of mutant IDH2 with IC50s of 100-400 nM for IDH2R140Q homodimer, IDH2R172K homodimer and IDH2WT/R140Q, IDH2WT/R172K. |
| PC-44670 |
AGI-6780
|
AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM. |
| PC-45550 |
Ivosidenib
mutant IDH1 inhibitor
|
Ivosidenib (AG-120) is a potent, mutant-selective inhibitor of IDH1 (isocitrate dehydrogenase type 1) with IC50 of 12 nM for mouse IDH1 R132H. |
