You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)

Request The Product List ofMEK (MAP2K) MEK (MAP2K)

Cat. No. Product Name Information
PC-43541

TAK-733

MEK inhibitor

TAK-733 (TAK733,TAK 733) is a potent, selective, allosteric inhibitor of MEK with IC50 of 3.2 nM (MEK1).
PC-43380

Cobimetinib R-enantiomer

Cobimetinib R-enantiomer (GDC-0973, XL518) is the R-enantiomer of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
PC-43369

Cobimetinib

MEK inhibitor

Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
PC-42877

PD318088

MEK1/2 inhibitor

PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
PC-42872

AZD8330

MEK1/2 inhibitor

AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM.
PC-42870

BIX02189

MEK5/ERK5 inhibitor

BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
PC-42857

AS703026

MEK1/2 inhibitor

AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
PC-42845

U0126

MEK inhibitor

U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM.
PC-42842

PD98059

MEK inhibitor

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK.
PC-62664

Vacquinol-1

Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
PC-62537

EBI-1051

MEK1 inhibitor

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.
PC-62503

E6201

MEK1/MEKK1 inhibitor

E 6201 (ER-806201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com