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Cat. No. Product Name Information
PC-21799

HRX-0233

MAP2K4 inhibitor

HRX-0233 (HRX0233) is a potent, selective MAP2K4 (MKK4) inhibitor, HRX-0233 is synergistic with RAS inhibitors in KRAS-mutant cancers.
PC-21237

NFX-179

MEK inhibitor

NFX-179 (Nedometinib, NFX179) is a potent, specific, topical, metabolically labile MEK1/2 inhibitor with biochemical IC50 of 135 nM (MEK1).
PC-20654

DK2403

MAP2K7 (MEK7) inhibitor

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
PC-49771

Binimetinib

MEK inhibitor

Binimetinib (ARRY-162, ARRY-438162, MEK162) is a potent, selective and non-competitive inhibitor of MEK1/2 with IC50 of 12 nM in cell-free assays.
PC-49634

DS03090629

MEK inhibitor

DS03090629 is a potent, selective, ATP-competitive and orally available MEK1/2 inhibitor, shows high affinity for the MEK protein regardless of its phosphorylation status (npMEK (inactive) Kd=0.11 nM, and pMEK (active) Kd=0.15 nM).
PC-38901

KZ-001

MEK inhibitor

KZ-001 is a highly potent and selective MEK 1/2 inhibitor with IC50 values of 7.4/64 nM, respectively, exhibits greater inhibition against BRAF- and KRAS-mutant tumor cells than AZD6244.
PC-38495

(R)-STU104

TAK1-MKK3 PPI inhibitor

(R)-STU104 is a potent, first-in-class TAK1-MKK3 porotein-protein interaction (PPI) inhibitor with SPR Kd of 71 nM for binding MKK3, disrupting the TAK1 phosphorylating MKK3.
PC-38429

Zapnometinib

MEK inhibitor

Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.
PC-38424

Tunlametinib

MEK inhibitor

Tunlametinib is a benzoheterocyclic compound as MEK modulator with potential for treatment of cancer and inflammation.
PC-38417

BT2

Angiogenesis inhibitor

BT2 is a thermostable small-molecule inhibitor of vascular permeability and angiogenesis, interacts with MEK1 and inhibits ERK phosphorylation, FosB/ΔFosB, and VCAM-1 expression.
PC-73276

INR119

MEK1/2 inhibitor

INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.
PC-73145

GDC-0623

MEK1 inhibitor

GDC-0623 (RG 7421) is a potent, selective, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM).

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