| Cat. No. |
Product Name |
Information |
| PC-61392 |
Otaplimastat
|
Otaplimastat is a potent matrix metalloproteinase (MMP) inhibitor. |
| PC-70316 |
ND-336
MMP2, 3, 9 inhibitor
|
ND-336 (ND336) is a potent, selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively. |
| PC-61148 |
PF-152
MMP13 inhibitor
|
PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM). |
| PC-60981 |
BK-1361
ADAM8 inhibitor
|
BK-1361 (BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM. |
| PC-60174 |
ND-378
MMP-2 inhibitor
|
ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM. |
| PC-42562 |
CTS-1027
MMP inhibitor
|
CTS-1027 (RS-130830) is a potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14, but not MMP1 and 7. |
| PC-42086 |
TAPI-2
ADAM17 inhibitor
|
TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE, ADAM17), ADAMs, and other MMPs, inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 uM, respectively. |
| PC-42904 |
Marimastat
MMP inhibitor
|
Marimastat (BB-2516, TA-2516) is a potent, broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively. |
| PC-21808 |
ADAM9i
ADAM9 inhibitor
|
ADAM9i is a specific small molecule inhibitor of ADAM9 protein with binding KD of 5.9 uM and enzyme IC50 of 5.2 uM, promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. |
| PC-21754 |
ADAMTS7 inhibitor 50
ADAMTS7 inhibitor
|
ADAMTS7 inhibitor 50 is a potent selective ADAMTS7 inhibitor with IC50 of 2 nM, 20-fold selective over ADAMTS12 and highly selective over a range of metalloproteases. |
| PC-21753 |
BAY-9835
ADAMTS7 inhibitor
|
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively. |
| PC-21674 |
TP0628103
MMP-7 inhibitor
|
TP0628103 is a highly potent, selective matrix metalloproteinase-7 (MMP-7) inhibitor with IC50 of 0.17 nM and 4.1 nM for human and mouse MMP-7, respectively. |
