| Cat. No. |
Product Name |
Information |
| PC-72035 |
IPR-179
MMP-2/9 inhibitor
|
IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively. |
| PC-35730 |
ARP101
MMP-2 inhibitor
|
ARP101 (ARP-101) is a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. |
| PC-35659 |
(R)-ND-336
MMP-9 inhibitor
|
(R)-ND-336 is a potent and selective small-molecule MMP-9 inhibitor with Ki of 19 nM, weakly inhibits MMP-2 and MMP-14 (Ki=127 and 119 nM), poorly inhibits other MMPs (Ki>10 uM). |
| PC-35373 |
ZLDI-8
ADAM17 inhibitor
|
ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus. |
| PC-35111 |
BAY-7598
MMP-12 inhibitor
|
BAY-7598 (BAY7598) is a potent, selective MMP12 inhibitor with IC50 of 0.085, 0.67 and 1.1 nM for human, murine, and rat MMP12, respectively. |
| PC-35033 |
BI-4394
MMP-13 inhibitor
|
BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM). |
| PC-63509 |
MMPI-1154
MMP-2 inhibitor
|
MMPI-1154 is a small molecule MMP-2 inhibitor with IC50 of 10/6.6/13/1.8 uM for MMP1/2/9/13, respectively. |
| PC-42999 |
SB-3CT
MMP2/9 inhibitor
|
SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM). |
| PC-63178 |
RO 28-2653
MMP inhibitor
|
RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM). |
| PC-62949 |
ADAMTS-5 inhibitor 15f
ADAMTS5 inhibitor
|
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
| PC-62948 |
ADAMTS-5 inhibitor 8
ADAMTS5 inhibitor
|
ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE. |
| PC-62947 |
Tanomastat
MMP inhibitor
|
Tanomastat (BAY 129566) is a potent,orally available, non-peptidic inhibitor of MMP-2, MMP-3 and MMP-9 with 11, 143 and 301 nM, respectively. |
