| Cat. No. |
Product Name |
Information |
| PC-73378 |
AS2690168
RANKL inhibitor
|
AS2690168 is a novel orally available, selective RANKL signal transduction inhibitor, reduces TRAP staining of sRANKL-stimulated RAW264 cells with IC50 of 0.28 uM, suppresses RANKL-induced osteoclastogenesis. |
| PC-38199 |
Bcl3 inhibitor JS6
Bcl-3 inhibitor
|
Bcl3 inhibitor JS6 is a novel potent, antimetastatic Bcl3 inhibitor, targeting the Bcl3-p50 interaction site. |
| PC-35770 |
SR12460
NF-κB inhibitor
|
SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM. |
| PC-35648 |
Vamorolone
NF-κB inhibitor
|
Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo. |
| PC-43543 |
BAY11-7082
NF-κB inhibitor, USP7/21 inhibitor
|
BAY11-7082 is a NF-κB inhibitor that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50=10 uM), also inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 uM and 0.96 uM, respectively. |
| PC-35289 |
Edasalonexent
NF-κB inhibitor
|
Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF-κB, salicylic acid and docosahexaenoic acid (DHA). |
| PC-63339 |
ABD345
RANKL inhibitor
|
ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation. |
| PC-62804 |
SEMBL
NF-κB inhibitor
|
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65. |
| PC-62417 |
Helenalin
p65 inhibitor
|
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway. |
| PC-62155 |
Withaferin A
NF-κB inhibitor
|
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism. |
| PC-62114 |
Isoquercetin
NF-κB modulator
|
Isoquercetin is a flavonoid and 3-O-glucoside of quercetin that displays selective cytotoxicity to cancer cells, primarily by inducing apoptosis and cell cycle arrest, regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. |
| PC-61961 |
IT-901
c-Rel/NF-κB inhibitor
|
IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM. |
