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Cat. No. Product Name Information
PC-20734

AG-1031

PC4 inhibitor

AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM).
PC-20217

NACK inhibitor UM-74

NACK inhibitor

UM-74 is a potent and specifc inhibitor of NACK (Notch activation complex kinase), directly blocks NACK recruitment to the Notch ternary complex (NTC).
PC-20216

Z271-0326

NACK inhibitor

Z271-0326 is a first-in-class, potent and specifc inhibitor of NACK (Notch activation complex kinase) with SPR KD value of 0.89 uM, directly blocks NACK recruitment to the Notch ternary complex (NTC).
PC-73042

RBPJ Inhibitor 1

RBPJ inhibitor

RBPJ Inhibitor 1 (RIN1) is a small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, inhibits RBPJ-VP16-dependent Hes1-Luciferase in AD-293 cells with IC50 of 0.2 uM.
PC-72454

NADI-351

Notch1 inhibitor

NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays.
PC-38269

CAD204520

SERCA inhibitor

CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM.
PC-38257

CB-103

Notch inhibitor

CB-103 (CB103) is an orally active small-molecule inhibitor of the Notch transcription activation complex, inhibits both ligand-dependent and ligand-independent Notch activation in cell-based assays (IC50=0.9-3.9 uM).
PC-38195

ASR490

Notch1 inhibitor

ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM).
PC-35995

NVS-ZP7-4

SLC39A7 inhibitor, Notch inhibitor

NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.
PC-63562

BMS-871

Notch inhibitor

BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
PC-63504

Yhhu-3792

Notch activator

Yhhu-3792 is a novel small molecule that enhances the self-renewal capability of neural stem cells (NSCs) in vitro and in vivo via activating the Notch signaling pathway.
PC-43039

LY3039478

Notch inhibitor

LY3039478 (Crenigacestat) is an exquisitely potent inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of 1 nM, also potently inhibits mutant Notch receptor activity.

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