| Cat. No. |
Product Name |
Information |
| PC-28235 |
DT-9081
EP4 antagonist
|
DT-9081 is a potent, selective and orally bioavailable antagonist of prostaglandin E2 receptor EP4 (EP4R), counteracts tumor-driven immunosuppression. |
| PC-28214 |
KF-0210
EP4 antagonist
|
KF-0210 is a potent, selective and oral EP4 receptor antagonist with binding IC50 of 18.6 nM, shows >500-fold selectivity over other prostaglandin receptors, including EP1, EP2, EP3, IP, DP1, and FP. |
| PC-27721 |
GR63799
EP3 agonist
|
GR63799X (GR63799) is a potent and selective prostanoid EP3 receptor agonist. |
| PC-27720 |
DG041
EP3 antagonist
|
DG-041 (DG041) is a potent and selective prostanoid EP3 receptor antagonist with IC50 of 4.6 nM and 8.1 nM in binding and FLIPR assay, respectively. |
| PC-27537 |
HTL0039732
EP4 antagonist
|
HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies. |
| PC-24436 |
ACT-1002-4271
EP2/EP4 antagonist
|
ACT-1002-4271 is a potent, selective dual EP2/EP4 antagonist with IC50 of 6 nM/3 nM for hEP2/hEP4 respectively in cAMP-based activity assays. |
| PC-35836A |
PGN 9856-isopropyl ester
EP2 receptor agonist
|
PGN 9856-isopropyl ester is the isopropyl ester, which is a potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3. |
| PC-35836D |
d4-PGN9856
EP2 receptor agonist
|
d4-PGN9856 is a d4-labelled PGN-9856, which is a potent, selective prostaglandin EP2 receptor agonist. |
| PC-21314 |
AZD1981
DP2 (CRTh2) inhibitor
|
AZD1981 is a potent and selective CRTh2 (DP2) antagonist with pIC50 of 8.4 (human recombinant DP2), with no significant affinity towards recombinant human DP1 receptors. |
| PC-20915 |
Selexipag
IP receptor agonist
|
Selexipag (NS-304) is an orally available, long-acting nonprostanoid prostacyclin receptor (IP receptor) agonist, the prodrug of the active form of MRE-269. |
| PC-20856 |
LY3127760
EP4 antagonist
|
LY3127760 is a potent, selective prostaglandin E4 (EP4) receptor antagonist with binding Ki of 58 nM (hEP4) and cAMP IC50 of 5.6 nM. |
| PC-20854 |
CR6086
EP4 antagonist
|
CR6086 (Vorbipiprant) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
