| Cat. No. |
Product Name |
Information |
| PC-20854 |
CR6086
EP4 antagonist
|
CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
| PC-20853 |
ONO-4578
EP4 antagonist
|
ONO-4578 (BMS-986310) is a potent, highly selective EP4 antagonist, potently inhibits the PGE2-induced cAMP production in CHO cells expressing mouse and human EP4 receptors with single-digit nM IC50. |
| PC-20852 |
AMX12006
EP4 antagonist
|
AMX12006 (AMX-12006) is a potent, selective, orally active antagonist of prostaglandin E2 (PGE2) receptor 4 (EP4) with IC50 of 4.3 nM in cAMP assays, shows no activity against EP1, EP2, EP3 receptors. |
| PC-20722 |
SQ-29548
TP antagonist
|
SQ-29548 (SQ-29,548) is a potent and specific antagonist of thromboxane-prostanoid (TP) receptor with binding Ki value of 4.1 nM. |
| PC-20715 |
Ifetroban sodium
TP antagonist
|
Ifetroban sodium (BMS-180291, CPI211) is a potent and highly selective antagonist of thromboxane A2/prostaglandin endoperoxide (TP) receptors, inhibits platelet aggregation induced by arachidonate (800 uM) and U-46,619 (10 uM) with IC50 of 7 and 21 nM, respectively. |
| PC-20529 |
AGN 225660
Prostaglandin Receptor antagonist
|
AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively. |
| PC-20528 |
AS604872
FP antagonist
|
AS604872 is a potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM, 158 nM and 323 nM for human, rat and mouse FP receptors, respectively. |
| PC-20527 |
SC-51322
EP1 antagonist
|
SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE2) receptor (EP1) with pA2 of 8.1. |
| PC-20526 |
BW A868C
DP1 antagonist
|
BW A868C is a potent, selective, competitive prostaglandin D2 (PGD2) antagonist, has no effect on other prostaglandin receptors (IP, EP1, EP2, TP and FP). |
| PC-20093 |
ACT-774312
CRTH2 inhibitor
|
ACT-774312 (ACT774312) is a potent and selective CRTH2 receptor antagonist with IC50 of 3 nM, 150-fold more potent than setipiprant in inhibiting PGD2-induced eosinophil cell shape change. |
| PC-20092 |
Setipiprant
CRTH2 inhibitor
|
Setipiprant (ACT-129968, KYTH-105) is a potent, selective and orally available CRTH2 antagonist with IC50 of 6 nM. |
| PC-20091 |
NVP-QAV680
CRTH2 inhibitor
|
NVP-QAV680 (QAV680) is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM and IC50 of 147 nM in 3H-PGD2 filtration binding assays and cAMP whole cell assays, respectively. |
