| Cat. No. |
Product Name |
Information |
| PC-22143 |
UH15-38
RIPK3 inhibitor
|
UH15-38 is a potent, specific receptor interacting protein kinase 3 (RIPK3) inhibitor with IC50 of 20 nM in NanoBRET assays, potently and selectively blocks IAV-triggered necroptosis in alveolar epithelial cells in vivo. |
| PC-21478 |
GSK840
RIPK3 inhibitor
|
GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis. |
| PC-49810 |
RIPK2 inhibitor 3
RIPK2 inhibitor
|
RIPK2 inhibitor 3 is a potent, selective inhibitor of RIP2 kinase (RIPK2), displays equivalent potency to inhibitor RIPK2 inhibitor 3 in biochemical assays, phosphate ester prodrug. |
| PC-49455 |
RI-962
RIPK1 inhibitor
|
RI-962 (RI 962) is a potent and selective RIPK1 inhibitor with IC50 of 5.9 nM in ADP-Glo assays. |
| PC-49126 |
GNE-684
RIPK1 inhibitor
|
GNE-684 is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively. |
| PC-47116 |
AS3334034
RIPK2 inhibitor
|
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively. |
| PC-38490 |
GSK-843
RIPK3 inhibitor
|
GSK-843 (GSK'843) is a specific small molecule receptor-interacting protein kinase 3 (RIPK3) inhibitor, binds to RIP3 kinase domain with high affinity (IC50=8.6 nM). |
| PC-73179 |
GSK2983559-AM
RIPK2 inhibitor
|
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM. |
| PC-73017 |
PK68
RIPK1 inhibitor
|
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively). |
| PC-73007 |
Necrostatin-34
RIPK1 inhibitor
|
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM. |
| PC-72999 |
GSK3145095
RIP1 inhibitor
|
GSK3145095 (GSK 3145095) is a potent, selective RIP1 Kinase (RIP1) inhibitor with IC50 of 6.3 nM. |
| PC-72533 |
Eclitasertib
RIPK1 inhibitor
|
Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM. |
