| Cat. No. |
Product Name |
Information |
| PC-49327 |
KSL-128114
Syntenin inhibitor
|
KSL-128114 (KLS 128114) is a highly potent and metabolically stable peptide inhibitor that binds to the PDZ1 domain of syntenin (KD=0.3 uM), inhibits SARS-CoV-2 infection by blocking the endosomal entry of the virus. |
| PC-49258 |
AB-00011778
SARS-CoV-2 entry inhibitor
|
AB-00011778 is a small molecule inhibitor of SARS-CoV-2 entry and the Spike/ACE2 interaction, inhibits viral replication with EC50 of 250 nM in A549-ACE2 cells, AB-00011778 is equally effective in impairing the S/ACE2 association in the different mutants. |
| PC-49191 |
SARS-CoV-2 PLpro inhibitor 7
PLpro inhibitor
|
SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM. |
| PC-49155 |
FOY-251
TMPRSS2 inhibitor
|
FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate. |
| PC-49140 |
JMX0286
SARS-CoV-2 3CLPro inhibitor
|
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells. |
| PC-49052 |
Z8539_0072
SARS-CoV-2 Nsp3 inhibitor
|
Z8539_0072 is a potent SARS-CoV-2 macrodomain inhibitor that binds to the NSP3 macrodomain of SARS-CoV-2 (Mac1) with IC50 of 460 nM. |
| PC-47067 |
RI173
SARS-CoV-2 inhibitor
|
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively. |
| PC-47020 |
Nafamostat mesylate
SARS-CoV-2 Inhibitor
|
Nafamostat mesylate (FUT-175) is a synthetic serine protease inhibitor with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral activities, blocks SARS-CoV-2 infection of Calu-3 cells with IC50 of 10 nM. |
| PC-38897 |
VE607
SARS-CoV entry inhibitor
|
VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of the SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM. |
| PC-38735 |
VV116
SARS-CoV-2 inhibitor
|
VV116 (Mindeudesivir, JT001) is a promising orally active remdesivir derivative against SARS-CoV-2, targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with IC50 of 0.67 uM. |
| PC-38696 |
Y180
SARS-CoV-2 Mpro inhibitor
|
Y180 is a highly potent, selective, covalent, and orally active SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 8.1 nM in enzymatic assays, binding Ki value of 1 nM. |
| PC-38568 |
SSAA09E3
SARS CoV entry inhibitor
|
SSAA09E3 is a small molecule inhibitor of SARS coronavirus with EC50 of 0.15 uM in infectious virus assay in Vero cells, preventing fusion of the viral membrane with the host cellular membrane. |
