| Cat. No. |
Product Name |
Information |
| PC-24614 |
TAK-676
STING agonist
|
TAK-676 (Dazostinag disodium) is a potent, selective stimulator of interferon genes (STING) agonist with highly selective binding and activation of STING proteins from various species, with Kd values of 0.01 uM, 0.008 uM, 0.011 uM, and 0.027 uM for mouse, rat, cynomolgus monkey, and human STING orthologs, respectively. |
| PC-24613 |
MK-2118
STING agonist
|
MK-2118 is a highly potent, noncyclic dinucleotide STING agonist. |
| PC-24587 |
HG381
STING agonist
|
HG381 is a new-generation, non-CDN STING agonist. |
| PC-24586 |
STING agonist A4
STING agonist
|
STING agonist A4 is a potent, specific STING agonist, effectively activates STING in both human THP1 and mouse RAW 264.7 cells with EC50 values of 0.06 and 14.15 μM, respectively. |
| PC-24560 |
STING agonist 12b
STING agonist
|
STING agonist 12b is a small molecule STING agonist with EC50 of 7.45 uM and 10.23 uM for human and murine STING respectively and Emax>100% for both, directly binds to carboxy-terminal domain (CTD) (IC50=1.92 uM) and stabilizes the hSTING protein. |
| PC-24559 |
STING synergist 67
STING synergist
|
STING synergist 67 is a selective STING synergist with EC50 of 20.5 uM, binds to carboxy-terminal domain (CTD) of STING (SPR KD=12.2 uM), amplifies cGAMP-induced pathway activation without inherent agonist properties. |
| PC-24094 |
Excavatolide B
STING inhibitor
|
Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM. |
| PC-24093 |
GHN105
STING inhibitor
|
GHN105 is a specific, orally bioavailable, covalent STING inhibitor, selectively targets the membrane-proximal Cys91 residue of STING, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 4.4 uM. |
| PC-24084 |
E7766 diammonium salt
STING agonist
|
E7766 diammonium salt is a macrocycle-bridged STING agonist with ITC Kd of 40 nM, exhibits broad pan-genotypic activity in all major human STING variants. |
| PC-23967 |
Astin C
STING inhibitor
|
Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling. |
| PC-23966 |
STING inhibitor 42
STING inhibitor
|
STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively. |
| PC-23719 |
DW18343
STING agonist
|
DW18343 is a specific, non-nucleotide stimulator of interferon genes (STING) agonist, binds to the LBD region of the STING protein, exhibits broad‐spectrum antitumor acitvity. |
