| Cat. No. |
Product Name |
Information |
| PC-26653 |
SH-273
STING agonist, PI3Kγ inhibitor
|
SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM). |
| PC-26652 |
STING inhibitor Y-320
STING inhibitor
|
Y-320 is a specific, allosteric small-molecule STING inhibitor, inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20-60 nM, blocks STING Golgi translocation and downstream signaling. |
| PC-26568 |
KSI-028
STING inhibitor
|
KSI-028 is a potent, specific STING inhibitor with IC50 of 0.652 uM in reporter assay in RAW264.7 cells. |
| PC-26425 |
UM-200
STING inhibitor
|
UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling. |
| PC-25518 |
Salvianolic acid A
STING modulator
|
Salvianolic acid A (SAL A, SAA) is a phenolic acid substance extracted from the plant Salvia miltiorrhiza Bunge, possessing antioxidant, neuroprotective effects, and anti-platelet aggregation properties, also effectively inhibits LCMV infection as a cap-dependent endonuclease inhibitor, also directly interacts with STING and regulates the TBK1/IRF3 signaling pathway. |
| PC-24987 |
STING activator diABZI-a1
STING agonist
|
STING activator diABZI-a1 is a potent, small molecule activator of STING, elicits IFNβ in human PBMCs with EC50 of 117 nM. |
| PC-24986 |
STING inhibitor diABZI-i
STING inhibitor
|
STING inhibitor diABZI-I (STING-IN-6) is a potent, small molecule inhibitor of STING, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 49 nM. |
| PC-24981 |
STING inhibitor 18
STING inhibitor
|
STING inhibitor 18 is a potent, orthosteric STING inhibitor / antagonist with IC50 of 68 nM in HAQ STING cGAMP displacement assay. |
| PC-24980 |
STING inhibitor THIQi
STING inhibitor
|
STING inhibitor THIQi is a potent, orthosteric STING inhibitor with IC50 of 84 nM in HAQ STING cGAMP displacement assays, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 29 nM. |
| PC-24871 |
Clonixeril
STING inhibitor
|
Clonixeril (CXL) is a highly potent, non-nucleotide hSTING modulator, has two modes of interaction with hSTING, shows weak agonist activity at micromolar concentrations, acts as a hSTING antagonist at <1 nM (EC50 < 1fM). |
| PC-24803 |
SR-301
STING agonist
|
SR-301 is a potent, non-nucleotide, oral small-molecule STING agonist with EC50 of 0.6 uM. |
| PC-24802 |
ZSA-215
STING agonist
|
ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. |
