| Cat. No. |
Product Name |
Information |
| PC-43348 |
R788 disodium salt
Syk inhibitor
|
Fostamatinib (R788 disodium salt) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
| PC-42880 |
R406
Syk inhibitor
|
R406 is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM. |
| PC-42815 |
R406 free base
Syk inhibitor
|
R406 (Tamatinib) free base is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM. |
| PC-63137 |
BAY 61-3606 hydrochloride
Syk inhibitor
|
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
| PC-63130 |
JTE-852
Syk inhibitor
|
JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively. |
| PC-63126 |
ASN-002
SYK/JAK inhibitor
|
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively, in biochemical assays. |
| PC-62789 |
Syk-IN-23
Syk inhibitor
|
Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model. |
| PC-61632 |
ER-27319 maleate
Syk inhibitor
|
ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk. |
| PC-61380 |
Lanraplenib
Syk inhibitor
|
Lanraplenib (GS-9876, GS9876) is a potent, selective, orally active Syk kinase inhibitor with IC50 of 9.5 nM. |
| PC-61366 |
Cevidoplenib
Syk inhibitor
|
Cevidoplenib (SKI-O-592) is a potent, selective spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM. |
| PC-70330 |
BI1002494 trifluoroacetate
Syk inhibitor
|
BI1002494 trifluoroacetate is a potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
| PC-70329 |
BI1002494
Syk inhibitor
|
BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
