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Cat. No. Product Name Information
PC-20861

Org 274179-0

TSHR antagonist

Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.
PC-20498

SYD5115

TSH-R antagonist

SYD5115 (SYD-5115) is a potent, selective and orally bioavailable thyrotropin receptor (TSH-R) antagonist with IC50 of 48 and 62 nM for rTSHR and hTSHR, respectively.
PC-43013

ML224

TSHR inverse agonist

ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM.
PC-60808

NCGC00379308

TSHR modulator

NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
PC-21867

TSHR ligand A35

THSR ligand

TSHR ligand A35 (NCATS-SM4420, NCGC00241808) is a specific Thyroid-stimulating hormone receptor (Thyrotropin receptor, TSHR) ligand, selectively activates TSHR-mediated cAMP accumulation in HEK-TSHR with EC50 of 240 nM, inhibits thyroid cancer (TC) cell proliferation and metastasis.
PC-20501

NCGC00229600

TSHR inverse agonist

NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM.
PC-20500

NIDDK/CEB-52

TSHR antagonist

NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM.
PC-20499

NCGC00161856

TSHR inverse agonist

NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM.
PC-35977

ML-109

ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule TSHR agonist with EC50 of 40 nM.

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