| Cat. No. |
Product Name |
Information |
| PC-63490 |
TrkA-IN-23
|
TrkA-IN-23 is a highly potent, subtype selective, peripherally restricted, allosteric TrkA inhibitor with IC50 of 10 nM, 180-fold selective over TrkB and 70-fold selective over TrkC in cell based assays. |
| PC-43266 |
LOXO-101 sulfate
|
LOXO-101 (ARRY-470, Larotrectinib) is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. |
| PC-43144 |
Entrectinib
|
Entrectinib (NMS-E628, RXDX-101, NMS-01191372) is a potent, ATP-competitive, orally available pan-TRK, ROS1 and ALK inhibitor with IC50 of 1/3/5/12/7 nM for TRKA/TRKB/TRKC/ALK/ROS1, respectively. |
| PC-63149 |
AZD 1332
|
AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK. |
| PC-62757 |
PQC 083
|
PQC 083 is a novel nerve growth factor (NGF) antagonist with IC50 of 7.0 uM, functionally inhibits NGF's effects on PC12 cell differentiation. |
| PC-62559 |
AG 879
|
Tyrphostin AG879 is a tyrphostin compound that inhibits NGF-dependent TrkA tyrosine phosphorylation in PC-12 cells with IC50 of 40 uM, also inhibits ErbB2 and VEGFR-2 (IC50=1 uM). |
| PC-61913 |
ALE-0540
|
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively. |
| PC-61701 |
PF-06273340
|
PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively. |
| PC-61490 |
LM11A-31
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
| PC-61489 |
LM11A-31 dihydrochloride
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
| PC-70266 |
Gambogic amide
|
A potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
| PC-70256 |
Belizatinib
|
A potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM. |
