| Cat. No. |
Product Name |
Information |
| PC-20760 |
TrkB agonist R13
TrkB agonist
|
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation. |
| PC-20475 |
TrkA inhibitor V1
|
TrkA inhibitor V1 is an isoform-selective inhibitor of TrkA kinase with IC50 of 199 nM, 470-fold selectivity over TrkB. |
| PC-20031 |
Emzeltrectinib
TrkB inhibitor
|
Emzeltrectinib is a potent, selective neurotrophic factor tyrosine kinase receptor TrkB inhibitor, shows potential for treatment of Trk kinase-mediated tumor. |
| PC-20024 |
Boditrectinib
pan-TRK inhibitor
|
Boditrectinib (AUM-601, NOV1601, HL5101, CHC-2014) is a highly selective, orally administered, which inhibits not only pan-TRK (TRKA, TRKB, and TRKC), but also resistance mutations of TRKs. |
| PC-73452 |
Utatrectinib
pan-Trk inhibitor
|
Utatrectinib (AZD7451, AZ12607092) is a potent, selective, small molecule pan-Trk (NTRK) inhibitor with IC50 of 0.2-3.0 nM against TrkA, TrkB, and TrkC. |
| PC-73435 |
Paltimatrectinib
Trk inhibitor
|
Paltimatrectinib is a small molecule Trk tyrosine kinase inhibitor with antineoplastic activity. |
| PC-73395 |
HJ-01
PTPσ-Trk inhibitor
|
HJ-01 is a small molecule that disrupts PTPσ-Trk interaction, enhances Trk signaling, and promotes sympathetic nerve regeneration over chondroitin sulfate proteoglycans (CSPGs). |
| PC-72114 |
Luxeptinib
Trk inhibitor
|
Luxeptinib (CG-806) is an orally bioavailable multikinase inhibitor with nanomolar potency against BTK, FLT3, TRK, STE/MAPK and Aurora kinase clusters. |
| PC-72113 |
ONO-7579
Trk inhibitor
|
ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor. |
| PC-35954 |
GZ389988
|
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis. |
| PC-35729 |
NSC49652
|
NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells. |
| PC-35679 |
CH7057288
|
CH7057288 (CH-7057288) is a novel potent and selective pan-TRK inhibitor with IC50 of 1.1/7.8/5.1 nM for TRKA/TRKB/TRKC, respectively. |
