| Cat. No. |
Product Name |
Information |
| PC-60327 |
Iperoxo
mAChR agonist
|
Iperoxo is an extremely potent muscarinic receptor agonist with EC50 of 2.12 nM and 8.47 nM for M2 and M4, respectively. |
| PC-60326 |
LY-2119620
|
LY 2119620 is a potent, specific,positive allosteric modulator of muscarinic M2 and M4 receptors. |
| PC-42096 |
hM3Dq-agonist-21
M3 mAChR agonist
|
hM3Dq-agonist-21 is a potent, selective human muscarinic acetylcholine M3 receptor (hM3Dq) full agonist with EC50 of 1.7 nM. |
| PC-21369 |
VU 0365114
M5 mAChR PAM
|
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors. |
| PC-20509 |
PIPE-359
M1 mAChR antagonist
|
PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R). |
| PC-20508 |
VU0415248
M1 mAChR antagonist
|
VU0415248 is a highly selective antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 0.4 uM and 0.18 uM for hM1R and rM1R, respectively. |
| PC-20104 |
Deschloroclozapine
DREADD agonist
|
Deschloroclozapine (DCZ) is a high-affinity and selective agonist for muscarinic-based DREADDs, shows nanomolar affinity for [3H]QNB-labeled hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
| PC-72783 |
VU6028418
M4 mAChR antagonist
|
VU6028418 (VU 6028418) is a potent, highly selective, orally bioavailable M4 mAChR antagonist for the treatment of dystonia and other movement disorders. |
| PC-38117 |
VU6007215
|
VU6007215 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 144 nM (hM4) and 295 nM (rM4).. |
| PC-38116 |
VU6009048
|
VU6009048 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 85 nM (hM4) and 379 nM (rM4).. |
| PC-35946 |
VU0467485
|
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4). |
| PC-35835 |
Spiropiperidine 1
|
Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors. |
