| Cat. No. |
Product Name |
Information |
| PC-24345 |
ML293
M4 mAChR PAM
|
ML293 is a selective, brain penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 1.3M (hM4), selective against the four other muscarinic subtypes. |
| PC-24344 |
ML253
M4 mAChR PAM
|
ML253 (VU0448088) is a potent, selective, CNS-penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 56 nM (hM4) and 176 nM (rM4), selective against the four other muscarinic subtypes. |
| PC-24343 |
VU6008677
M4 mAChR PAM
|
VU6008677 is a potent, selective M4 mAChR positive allosteric modulator (PAM) with EC50 of 163 nM (hM4), inactive against hM2. |
| PC-24342 |
VU6016235
M4 mAChR PAM
|
VU6016235 is a potent, selective, orally active M4 mAChR positive allosteric modulator (PAM) with EC50 of 140 nM (hM4), has >148-fold selectivity over other subtypes mAChRs. |
| PC-24341 |
VU6045422
M1 mAChR PAM
|
VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1). |
| PC-23644 |
T‐495
M1 mAChR PAM
|
T-495 is a potent and highly selective positive allosteric modulator of M1 muscarinic acetylcholine receptor with EC50 of 649 nM. |
| PC-23642 |
BQCA
M1 mAChR PAM
|
BQCA is a highly selective positive allosteric modulator (PAM) of M1 mAChR with EC50 of 267 nM, shows high intrinsic M1 agonist activity. |
| PC-23594 |
ADS10227
M2R/M4R antagonist
|
ADS10227 is a potent muscarinic receptor antagonist with binding Ki of 2.8 nM and 5.1 nM for human muscarinic M2 and M4 receptors (hM2R and hM4R) respectively. |
| PC-23358 |
BAY 2413555
M2 mAChR PAM
|
BAY 2413555 is a potent, selective positive allosteric modulator of M2 muscarinic acetylcholine receptor (M2 mAChR, M2R) with EC50 of 2.0 nM in functional M2-GIRK assays. |
| PC-23330 |
Pirenzepine
M1 mAChR antagonist
|
Pirenzepine (LS519, Pirenzepin, Gastrozepin) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist, shows gastric secretion-inhibitory action but without central-nervous sedation. |
| PC-23023 |
Darifenacin
CHI3L1 inhibitor, M3 mAChR inhibitor
|
Darifenacin (UK-88525) is a potent, selective M3 muscarinic receptor antagonist with pKi of 8.9, also inhibits CHI3L1(Chitinase 3-like 1) and PDAC cell growth. |
| PC-22961 |
VU6007496
M1 mAChR PAM
|
VU6007496 is a highly selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 228 nM (hM1), with minimal M1 agonism (EC50>10 μM). |
