| Cat. No. |
Product Name |
Information |
| PC-42096 |
DREADD agonist compound 21
hM3Dq agonist
|
DREADD agonist compound 21 (hM3Dq agonist) is a potent, selective human muscarinic acetylcholine M3 receptor (hM3Dq) full agonist with EC50 of 1.7 nM. |
| PC-45939 |
Cevimeline hydrochloride
mAChR M1 agonist
|
Cevimeline hydrochloride is a potent M1-selective muscarinic agonist. |
| PC-45185 |
Clozapine N-oxide
DREADD agonist, M4 mAChR agonist
|
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist, activates the DREADD receptor hM3Dq and hM4Di, a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor agonist with EC50 of 11 nM. |
| PC-43305 |
Batefenterol
MABA, OTUB1 inhibitor
|
Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively, also is a small-molecule inhibitor of deubiquitinase OTUB1 with SPR KD of 23.5 uM. |
| PC-25835 |
Xanomeline
M1 mAChR agonist
|
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-25834 |
ML-007
M1/M4 mAChR agonist
|
ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors. |
| PC-24948 |
Direclidine
M4 mAChR PAM
|
Direclidine is a selective muscarinic M4 receptor positive allosteric modulator. |
| PC-24879 |
VU6008055
M4 mAChR PAM
|
VU6008055 (AF98943) is a potent, highly selective, orally bioavailable M4 muscarinic acetylcholine receptor positive allosteric modulator with EC50 of 73.4 nM and 19.5 nM for human and rat M4 receptor respectively. |
| PC-24783 |
AC-42
M1 mAChR agonist
|
AC-42 is a poent selective allosteric agonist of M1 muscarinic receptor with EC50 of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. |
| PC-24782 |
77-LH-28-1
M1 mAChR agonist
|
77-LH-28-1 is a potent, selective, CNS penetrant, and M1 muscarinic receptor agonist, potently stimulates intracellular calcium mobilization in CHO-hM1 cells with pEC50 value of 8.1. |
| PC-24345 |
ML293
M4 mAChR PAM
|
ML293 is a selective, brain penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 1.3M (hM4), selective against the four other muscarinic subtypes. |
| PC-24344 |
ML253
M4 mAChR PAM
|
ML253 (VU0448088) is a potent, selective, CNS-penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 56 nM (hM4) and 176 nM (rM4), selective against the four other muscarinic subtypes. |
