| Cat. No. |
Product Name |
Information |
| PC-35747 |
VU6007477
|
VU6007477 is a novel potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity. |
| PC-35626 |
GSK1034702
|
GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5. |
| PC-35576 |
TAK-071
|
TAK-071 (TAK071) is a novel potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells. |
| PC-35489 |
VU0467154
|
VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM. |
| PC-35486 |
VU6004256
|
VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM). |
| PC-35482 |
PF-06827443
|
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM. |
| PC-35477 |
PF-06764427
|
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM. |
| PC-43517 |
Xanomeline oxalate
|
Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-43505 |
VU0152100
|
VU0152100 (VU152100) is a potent, selective positive allosteric modulator of M4 mAChR with EC50 of 0.38 uM for rat M4. |
| PC-63491 |
VU6007678
|
VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM. |
| PC-63463 |
VU0486846
|
VU0486846 is a novel potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM. |
| PC-63443 |
LSN3172176
|
LSN3172176 is a novel potent, selectiive M1 mAChR partial agonist (EC50 2.4-7.0nM, Emax 43%-73%), shows binding selectivity for M1 mAChRs (Kd=1.5 nM). |
