| Cat. No. |
Product Name |
Information |
| PC-45994 |
JQ-1 carboxylic acid
BET inhibitor
|
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones. |
| PC-42110 |
BI-9564
BRD9 inhibitor
|
BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM. |
| PC-42220 |
AZD5153 6-Hydroxy-2-naphthoic acid
BRD4 bromodomain inhibitor
|
AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM. |
| PC-45507 |
PFI-4
BRPF1 inhibitor
|
PFI-4 is a potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3. |
| PC-42109 |
BI-7273
BRD9 inhibitor
|
BI-7273 is a potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay. |
| PC-45780 |
PF-CBP1 hydrochloride
CBP/p300 inhibitor
|
PF-CBP1 hydrochloride is a potent, highly selective inhibitor of the CBP and p300 bromodomains with IC50 of 125 nM and 363 nM, respectively. |
| PC-42090 |
GSK-6853
BRPF1 inhibitor
|
GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1. |
| PC-42168 |
CPI-637
CBP/p300 inhibitor
|
A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM. |
| PC-43808 |
I-BET726
BET inhibitor
|
I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively. |
| PC-42230 |
TPOP146
CBP/p300 inhibitor
|
TPOP146 is a potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)). |
| PC-42029 |
Mivebresib
BET inhibitor
|
Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively. |
| PC-22158 |
BBC0403
BRD2 inhibitor
|
BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis. |
