| Cat. No. |
Product Name |
Information |
| PC-62274 |
RVX2135
BET inhibitor
|
RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively. |
| PC-62273 |
TP-472
BRD9/BRD7 inhibitor
|
TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay). |
| PC-62272 |
BI 7271
BRD9/BRD7 inhibitor
|
BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9. |
| PC-62271 |
BI 7189
BRD9 inhibitor
|
BI 7189 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9, displays >1,000 fold selectivity over the bromodomains of BRD4. |
| PC-62270 |
BMS 986158
|
BMS 986158 is a potent and selective BET inhibitor, disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. |
| PC-62269 |
BAZ2-ICR
|
BAZ2-ICR is a potent, selective and cell-active inhibitor of BAZ2A (Kd=109 nM, IC50=130 nM) and BAZ2B (Kd=170 nM, IC50=180 nM) bromodomains. |
| PC-62224 |
biBET
BET inhibitor
|
biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively. |
| PC-61977 |
ZEN-3694
BET inhibitor
|
ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range. |
| PC-61863 |
RVX-297
|
RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively. |
| PC-61740 |
FT-001
BET inhibitor
|
FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1. |
| PC-61641 |
GNE-049
CBP/p300 inhibitor
|
GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively. |
| PC-50010 |
PLX51107
BET inhibitor
|
PLX51107 is a novel structurally distinct BET inhibitor that inhibits all four BET family proteins BRD2, BRD3, BRD4, and BRDT with low nanomolar potency. |
