| Cat. No. |
Product Name |
Information |
| PC-20573 |
OTX-015
BET bromodomain inhibitor
|
Birabresib (OTX-015) is a potent, competitive inhibitor of BET bromodomain BRD2, BRD3, and BRD4 with EC50 of 10-19 nM, inhibits binding of BRD2, BRD3, and BRD4 to acetylated histone H4 (AcH4) with IC50 of 92-112 nM. |
| PC-20463 |
BI 1702135
SMARCA2 binder
|
BI 1702135 (Compound 4) is a potent SMARCA2 binder for targeted protein degradation (PROTAC) design as BI 1810284 (ACBI2, Cat. PC-20464). |
| PC-20343 |
FHT-2344
SMARCA4/2 inhibitor
|
FHT-2344 (FHT2344) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 26 and 13 nM respectively, the ATPase component of the BAF complex. |
| PC-20342 |
FHT-1015
SMARCA4/2 inhibitor
|
FHT-1015 (FHT1015) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 4 and 5 nM respectively, the ATPase component of the BAF complex. |
| PC-20312 |
SJ1461
BET inhibitor
|
SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively. |
| PC-20181 |
XS018661
ENL/AF9 YEATS inhibitor
|
XS018661 (XS 018661) is a potent first-in-class inhibitor of the YEATS domains of ENL and AF9 with Kd of 754/523 nM, IC50 of 1.6/3.0 uM, respectively. |
| PC-20178 |
L Moses dihydrochloride
PCAF inhibitor
|
L Moses (PCAF BRD inhibitor L-45) is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4. |
| PC-20163 |
CG223
BET inhibitor
|
CG223 (CG14223) is a potent and specific inhibitor of BET proteins with Kd of 45 nM for the C-terminal bromodomain of BRD3 (i.e. BRD3(2)) to 370 nM for the N-terminal bromodomain of BRDT (i.e. BRDT(1)). |
| PC-20162 |
I-BET282
BET inhibitor
|
I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins with pIC50 of 7.4 for BRD4-BD1, ITC Kd of 47.5 nM for BRD4, shows equivalent potency against BD1 and BD2 domains. |
| PC-20161 |
I-BET282E
BET inhibitor
|
I-BET282E (I-BET282 mesylate) is the mesylate salt of I-BET282, I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins. |
| PC-20160 |
CG13250
BET inhibitor
|
CG13250 (CG 13250, CG250) is a potent, selective and orally bioavailable BET bromodomain inhibitor with Kd of 44 nM (BRD4), IC50 of 1.1 uM (BRD4 BD1+BD2). |
| PC-20123 |
BI-4827
|
BI-4827 (BI 4827) is the negative control compound of BI-7190, which is a potent, selective chemical probe targeting the bromodomain of BPTF. |
