| Cat. No. |
Product Name |
Information |
| PC-72942 |
BRM011
BRM/BRG1 inhibitor
|
BRM011 (dual BRM and BRG1 inhibitor 11) is a potent, selective, allosteric dual BRM and BRG1 inhibitor with IC50 of <5 nM for both. |
| PC-72866 |
CRCM5484
BET-BD2 inhibitor
|
CRCM5484 is a potent, BET BDII-selective inhibitor with IC50 of 130/20/71 nM for BRD4-BD2/BRD3-BD2/BRD2-BD2, respectively. |
| PC-72821 |
XP-524
BET/EP300 inhibitor
|
XP-524 (XL-223, XP524) is a potent, dual-BET/EP300 inhibitor, inhibits BRD4-BD (IC50=5.8 nM) and BRD4-BD2 (IC50=1.5 nM), binds strongly to and inhibits EP300 and CBP proteins with IC50 of 28 and 116 nM, respectively. |
| PC-72789 |
NVS-BPTF-1
BPTF bromodomain inhibitor
|
NVS-BPTF-1 is the first highly potent and selective BPTF-bromodomain inhibitor with IC50 of 56 nM in an AlphaScreen assay and Kd of 71 nM in a BLI assay. |
| PC-72779 |
AZ13824374
ATAD2 inhibitor
|
AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM. |
| PC-72758 |
BPTF inhibitor BZ1
BPTF inhibitor
|
BPTF inhibitor BZ1 (BPTF-IN-BZ1) is a potent, selective, cell-active inhibitor of bromodomain PHD finger transcription factor (BPTF) with Kd of 6.3 nM, >350-fold selectivity over BET bromodomains. |
| PC-72713 |
GAS41 YEATS inhibitor 19
GAS41 YEATS domain inhibitor
|
GAS41 YEATS inhibitor 19 (GAS41 YEATS-IN-19) is potent, selective, cell-permeable dimeric inhibitor of GAS41 YEATS domain with IC50 of 18 nM (AlphaScreen competition assay). |
| PC-72707 |
TAF1(2) inhibitor 23
TAF1(2) inhibitor
|
TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains. |
| PC-72706 |
LM146
PB1 bromodomain inhibitor
|
LM146 (LM-146) is a potent and selective inhibitor of pan-PB1 bromodomains (Polybromo-1 protein, PBRM1 or BAF180), binds to PB1(2), PB1(5), and SMARCA2B with KD values of 110, 61, and 2100 nM, respectively. |
| PC-72676 |
UM-002
BRD4 inhibitor
|
UM-002 is a highly potent, selective, brain penetrant BRD4 bromodomain inhibitor with IC50 of 8.8 and 2.4 nM for BRD4-1 and BRD4-2, respectively. |
| PC-72646 |
I-BET567
pan-BET inhibitor
|
I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT. |
| PC-72573 |
SR-0813
ENL/AF9 YEATS inhibitor
|
SR-0813 (SR0813) is a potent, selective, dual ENL/AF9 YEATS domain inhibitor (IC50 =25/311 nM). |
